Hot-Melt  Extrusion  technique or named Melt Extrusion technique， It's a new preparation technology that the Europe, North America and Japan vigorously developed in recent years . The main function is to improve the solubility of the drug, the preparation of sustained release formulations……

​        Hot-Melt  Extruder Basic parameters ：

Capacity ：3kg/h，

Screw diameter  (mm) ： 15.6

Screw groove depth  (mm) ： 3.3

Maximum drive power （Kw) ： 1.5

Maximum speed （rpm) ： 600

M aximum output torque （N/m) ： 33

Molding caliber （mm） ： 2

Minimum sample weight （g） ：30

Residues （ml） ：20

Hot-melt extruder Technical advantages:

l Continuous production

l Excellent reproducibility

l No dust pollution

l Online control

​Hot-melt extruder Applications:

1. Adalat SL  → Nifedipine

Accessories reinforcing material ：PEG

2. Cris-PEG  → Griseofulvin

Accessories reinforcing material ：PEG

3. K aletra    → Lopinavir / ritonavir

Accessories reinforcing material ： Copovidone

4. Rezulin    → Troglitazone

Accessories reinforcing material ： Povidone

Hot-melt extruder principle

l Hot-melt extruder technology ： T wo or more of the samples were placed in a temperature controlled barrel ， t ogether heated to a molten state . Under the action of the screw, the samples were cut, mix, and finally through a die under a certain pressure ，b ecome dispersed uniformly shaped product

l Hot-melt extruder basic idea ： Place multiple segments threaded element within different functions in the axial space . So that multiple samples size decreases, and mutual penetration and exchange ， e ventually achieve molecular level mixing 。